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  • In addition, general anesthetics may produce additive CNS depression when used in patients taking tricyclic antidepressants.
  • Lower doses than usually prescribed for either the phenothiazine or the TCA may be required.
  • Treatment with clozapine has been associated with QT prolongation, torsade de pointes TdP, cardiac arrest, and sudden death.
  • For years, physostigmine was used as an adjunct to the treatment of TCA overdose; however, its efficacy was limited to addressing anticholinergic effects.

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